[Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report].
Identifieur interne : 000020 ( Main/Exploration ); précédent : 000019; suivant : 000021[Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report].
Auteurs : Nourdine Attiya [Maroc]Source :
- The Pan African medical journal [ 1937-8688 ] ; 2020.
Descripteurs français
- KwdFr :
- Anémie (diagnostic), Anémie (induit chimiquement), Carence en vitamine B12 (diagnostic), Carence en vitamine B12 (induit chimiquement), Diabète (traitement médicamenteux), Diagnostic buccal (MeSH), Femelle (MeSH), Glossite (diagnostic), Glossite (induit chimiquement), Humains (MeSH), Hypoglycémiants (administration et posologie), Hypoglycémiants (effets indésirables), Metformine (administration et posologie), Metformine (effets indésirables), Sujet âgé (MeSH).
- MESH :
- administration et posologie : Hypoglycémiants, Metformine.
- diagnostic : Anémie, Carence en vitamine B12, Glossite.
- effets indésirables : Hypoglycémiants, Metformine.
- induit chimiquement : Anémie, Carence en vitamine B12, Glossite.
- traitement médicamenteux : Diabète.
- Diagnostic buccal, Femelle, Humains, Sujet âgé.
English descriptors
- KwdEn :
- Aged (MeSH), Anemia (chemically induced), Anemia (diagnosis), Diabetes Mellitus (drug therapy), Diagnosis, Oral (MeSH), Female (MeSH), Glossitis (chemically induced), Glossitis (diagnosis), Humans (MeSH), Hypoglycemic Agents (administration & dosage), Hypoglycemic Agents (adverse effects), Metformin (administration & dosage), Metformin (adverse effects), Vitamin B 12 Deficiency (chemically induced), Vitamin B 12 Deficiency (diagnosis).
- MESH :
- chemical , administration & dosage : Hypoglycemic Agents, Metformin.
- chemical , adverse effects : Hypoglycemic Agents, Metformin.
- chemically induced : Anemia, Glossitis, Vitamin B 12 Deficiency.
- diagnosis : Anemia, Glossitis, Vitamin B 12 Deficiency.
- drug therapy : Diabetes Mellitus.
- Aged, Diagnosis, Oral, Female, Humans.
Abstract
Metformin is the first line treatment for type 2 diabetes. It is also indicated in patients with insulin-resistant type 1 diabetes. It has several benefic effects on carbohydrate metabolism, weight loss and vascular protection. However, it can also cause serious adverse reactions such as the risk of anemia associated with long term use. It has been reported that long-term metformin use might reduce serum vitamin B12 levels. Oral signs combining Hunter glossitis and stomatodynia may be revelatory and lead to early diagnosis of vitamin B12 deficiency. We here report the case of a female patient who had had these oral signs for 2 years and whose laboratory tests revealed normocytic anemia with iron and vitamin B12 deficiency. The diagnosis of vitamin B12 deficiency due to long-term metformin was suspected while excluding other potential causes. Intramuscular hydroxocobalamin injection associated with oral iron led to the normalization of serum levels and to the disappearance of clinical signs. The patient was referred to a specialized center for further etiological assessment. This clinical case highlights the essential role of dentists in early diagnosis of vitamin B12 deficiency and the prevention of its progression, which can be dramatic in the case of late discovery.
DOI: 10.11604/pamj.2020.37.280.19776
PubMed: 33598094
PubMed Central: PMC7864276
Affiliations:
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xml:lang="fr"><term>Hypoglycémiants</term><term>Metformine</term></keywords><keywords scheme="MESH" qualifier="induit chimiquement" xml:lang="fr"><term>Anémie</term><term>Carence en vitamine B12</term><term>Glossite</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Diabète</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Oral</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Diagnostic buccal</term><term>Femelle</term><term>Humains</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Metformin is the first line treatment for type 2 diabetes. It is also indicated in patients with insulin-resistant type 1 diabetes. It has several benefic effects on carbohydrate metabolism, weight loss and vascular protection. However, it can also cause serious adverse reactions such as the risk of anemia associated with long term use. It has been reported that long-term metformin use might reduce serum vitamin B12 levels. Oral signs combining Hunter glossitis and stomatodynia may be revelatory and lead to early diagnosis of vitamin B12 deficiency. We here report the case of a female patient who had had these oral signs for 2 years and whose laboratory tests revealed normocytic anemia with iron and vitamin B12 deficiency. The diagnosis of vitamin B12 deficiency due to long-term metformin was suspected while excluding other potential causes. Intramuscular hydroxocobalamin injection associated with oral iron led to the normalization of serum levels and to the disappearance of clinical signs. The patient was referred to a specialized center for further etiological assessment. This clinical case highlights the essential role of dentists in early diagnosis of vitamin B12 deficiency and the prevention of its progression, which can be dramatic in the case of late discovery.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33598094</PMID><DateCompleted><Year>2021</Year><Month>02</Month><Day>23</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>23</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1937-8688</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>The Pan African medical journal</Title><ISOAbbreviation>Pan Afr Med J</ISOAbbreviation></Journal><ArticleTitle>[Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report].</ArticleTitle><Pagination><MedlinePgn>280</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.11604/pamj.2020.37.280.19776</ELocationID><Abstract><AbstractText>Metformin is the first line treatment for type 2 diabetes. It is also indicated in patients with insulin-resistant type 1 diabetes. It has several benefic effects on carbohydrate metabolism, weight loss and vascular protection. However, it can also cause serious adverse reactions such as the risk of anemia associated with long term use. It has been reported that long-term metformin use might reduce serum vitamin B12 levels. Oral signs combining Hunter glossitis and stomatodynia may be revelatory and lead to early diagnosis of vitamin B12 deficiency. We here report the case of a female patient who had had these oral signs for 2 years and whose laboratory tests revealed normocytic anemia with iron and vitamin B12 deficiency. The diagnosis of vitamin B12 deficiency due to long-term metformin was suspected while excluding other potential causes. Intramuscular hydroxocobalamin injection associated with oral iron led to the normalization of serum levels and to the disappearance of clinical signs. 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IdType="pubmed">22792601</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014 Jun 24;9(6):e100379</Citation><ArticleIdList><ArticleId IdType="pubmed">24959880</ArticleId></ArticleIdList></Reference><Reference><Citation>Am Fam Physician. 2017 Sep 15;96(6):384-389</Citation><ArticleIdList><ArticleId IdType="pubmed">28925645</ArticleId></ArticleIdList></Reference><Reference><Citation>Cureus. 2017 Aug 18;9(8):e1577</Citation><ArticleIdList><ArticleId IdType="pubmed">29057189</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Maroc</li></country></list><tree><country name="Maroc"><noRegion><name sortKey="Attiya, Nourdine" sort="Attiya, Nourdine" uniqKey="Attiya N" first="Nourdine" last="Attiya">Nourdine Attiya</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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